611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net
Health Sciences
Resources
Basic InformationLatest News
AHA News: Obesity Harms Brain Health Throughout Life – Yet Scientists Don't Know WhyEven a Little Exercise May Help Slow Parkinson'sScientists ID Genes That Make Your ​FingerprintsCould the 'Alzheimer's Gene' Raise Risks for Severe COVID-19?Genes 'Switched On' Much Earlier in Human Embryos Than ThoughtFormaldehyde in the Workplace Tied to Later Brain IssuesAHA News: Making a Lifetime of Good Brain Health a Global PriorityNFL Players Face 4 Times the Odds of ALSCould Gene Therapy Help Cure Sickle Cell Disease?Toxins in Wildfire Smoke May Make Their Way Into BrainMRI Might Spot Concussion-Linked CTE in Living PatientsCertain Blood Thinners Can Raise Risk of 'Delayed' Bleeding After Head InjuryAHA News: Former NFL Players With Lots of Concussions May Have Higher Stroke RiskMore Years Playing Football, More Brain Lesions on MRI: StudyNew Insights Into What Might Drive Parkinson's DiseaseBrain's 'White Matter' Changes in People With AutismWearable Vibration Device May Ease Parkinson's TremorNeurologists' Group Issues New Treatment Guidelines for Early Parkinson'sGene Therapy Could Be Big Advance Against HemophiliaBlood Test Looks at Patients' Whole Genome to Spot Rare Inherited DiseasesSales of Unproven, Unapproved Stem Cell Therapies Are BoomingHow Bilingual Brains Shift Quickly Between LanguagesMouse Study Offers Hope for Gene Therapy Against Parkinson's DiseaseInsomnia Tied to Raised Risk of AneurysmAHA News: Could the Path to Better Brain Health Involve Better Mouth Care?More Americans Are Dying From Parkinson's Disease: StudyTen Years On, Gene Therapy Still Beating Most Cases of 'Bubble Boy' Immune DiseaseResearchers Find Better Way to Fight Breast Cancer That Has Spread to BrainShape, Size of Brain Arteries May Predict Stroke RiskTracking Key Protein Helps Predict Outcomes in TBI PatientsSigns of Early Alzheimer's May Be Spotted in Brain StemCould Cholesterol Help Drive Alzheimer's Disease?Insights Into Genes Driving Epilepsy Could Help With TreatmentFewer American Adults Are Getting Malignant Brain TumorsLong-Term Outlook for Most With Serious Brain Injury Is Better Than ThoughtStroke Prevented His Speech, But Brain Implant Brought It BackWHO Calls for Global Registry of Human Genome EditingScientists Track Spirituality in the Human BrainNew Insights Into How Eating Disorders Alter the BrainGene Differences Could Have Black Patients Undergoing Unnecessary BiopsiesCRISPR Therapy Fights Rare Disease Where Protein Clogs OrgansNew Genetic Insights Into Cause of ALSDeep Brain Stimulation Therapy May Help Parkinson's Patients Long TermAmazon Tribe Could Hold Key to Health of Aging BrainsMan Blind for 40 Years Regains Some Sight Through Gene TherapyNew Insights Into Treating Mild Head Injuries'Ghosts and Guardian Angels': New Insights Into Parkinson's HallucinationsHigher Education Won't Help Preserve the Aging Brain: StudyScientists Create Embryos With Cells From Monkeys, Humans'Game of Thrones' Study Reveals the Power of Fiction on the Mind
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

New Insights Into What Might Drive Parkinson's Disease

HealthDay News
by Robert Preidt
Updated: Nov 29th 2021

new article illustration

MONDAY, Nov. 29, 2021 (HealthDay News) -- A defect in the blood-brain barrier may play a role in Parkinson's disease, a groundbreaking research study suggests.

The blood-brain barrier acts as a filter to keep out toxins while still allowing the passage of nutrients to nourish the brain. This study found that in some people with Parkinson's, the blood-brain barrier doesn't work right.

In these patients, the barrier traps toxins in the brain, prevents glucose and other nutrients from getting in, and permits inflammatory cells and molecules from the body to enter and damage the brain.

"Much work remains to be done, but just knowing that a patient's brain vascular system is playing a significant role in the progression of the disease is a very promising discovery," said senior study author Charbel Moussa. He is director of the Translational Neurotherapeutics Program at Georgetown University Medical Center in Washington, D.C.

The findings could point the way to new treatments for Parkinson's disease, according to the report published online recently in the journal Neurology: Genetics.

"To our knowledge, this is the first study to show that the body's blood-brain barrier potentially offers a target for the treatment for Parkinson's disease," Moussa said in a university news release.

The findings stem from an advanced genome study of the cerebrospinal fluid of 75 patients with severe Parkinson's disease. The results were compared before and after off-label treatment with the leukemia drug nilotinib, or with a placebo.

The new results could help explain earlier findings that the drug nilotinib was associated with a reduction in movement problems and an increase in quality of life in Parkinson's patients.

"Not only does nilotinib flip on the brain's garbage disposal system to eliminate bad toxic proteins, but it appears to also repair the blood-brain barrier to allow this toxic waste to leave the brain and to allow nutrients in," Moussa said.

"Parkinson's disease is generally believed to involve mitochondrial or energy deficits that can be caused by environmental toxins or by toxic protein accumulation. It has never been identified as a vascular disease," he added.

More information

The U.S. National Institute on Aging has more about Parkinson's disease.

SOURCE: Georgetown University Medical Center, news release, Nov. 12, 2021