611 W. Union Street
Benson, AZ 85602
(520) 586-0800

member support line
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line


611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line


powered by centersite dot net
Mental Disorders
Basic InformationLookupsLatest News
Psychiatric Disorders and Type 2 Diabetes Often Go TogetherMany Psychiatric Patients Are Getting Risky Drug Gabapentin 'Off-Label'Trauma in Childhood Can Harm Health for a Lifetime: StudyToo Much Sitting May Be Bad for Your Mental HealthAHA News: Researchers Start to Uncover the Pandemic's Impact on Mental HealthLittle Change Seen in Americans' Use of Mental Health Services During PandemicU.S. Psychologists See Big Spike in Demand for Mental Health CareAHA News: Another Barrier for Black and Hispanic People: Good Mental Health CareAdults With Autism, Mental Illness May Be at Higher Risk for Severe COVIDLyme Disease Can Wreak Havoc on Mental HealthAHA News: Wildfires Can Cause Mental Health Damage That Smolders Years After the Flames Go OutPandemic Boosted Paranoia and Conspiracy Theories, Study ConfirmsMany U.S. Mass Shooters Had Untreated Mental Illness: StudyTelehealth Is Growing in Use, Acceptance Among Americans: PollWorry, Depression Can Plague Folks Who Get Implanted DefibrillatorsHigh-Profile Police Brutality Cases Harm Black Americans' Mental Health: StudyAmericans Still Avoiding ERs in Pandemic, But Uptick Seen in Mental Health CrisesCould ADHD Raise Odds for More Serious Psychiatric Ills?Mental Health 'Epidemic' Threatens Communities of Color Amid COVID-19Mental Illness Not a Factor in Most Mass ShootingsHistory of Mental Illness Tied to Earlier Onset of Alzheimer's DiseaseMental Health Trauma Plagues Wildfire Survivors1 in 3 Young Americans Prescribed a Psychiatric Drug Misuses Them: StudySurvey Shows Mental Woes Spiked in U.S. Pandemic's First MonthsPandemic Taking Big Mental Health Toll on Health Care WorkersRap Music Is Putting Mental Health in the SpotlightTake Care of Your Mental Health During PandemicU.S. Soldier in Custody Following Slaying of 5 Americans in Iraq
Questions and AnswersLinksBook Reviews
Related Topics

Anxiety Disorders
Bipolar Disorder
Depression: Depression & Related Conditions
Eating Disorders

Many Psychiatric Patients Are Getting Risky Drug Gabapentin 'Off-Label'

HealthDay News
by By Amy Norton HealthDay Reporter
Updated: Nov 22nd 2021

new article illustration

MONDAY, Nov. 22, 2021 (HealthDay News) -- Most prescriptions for the medication gabapentin are for unapproved uses -- and many patients end up taking it along with drugs that create potentially dangerous interactions.

That's the conclusion of a new study that looked at "off-label" use of gabapentin. In the United States, the drug is officially approved for treating certain seizures and some forms of nerve pain.

It's known, however, that gabapentin is commonly prescribed for other uses, including various types of pain conditions and psychiatric disorders like depression and anxiety.

The new study highlights just how widespread that off-label use is: Of almost 130 million outpatient visits where gabapentin was prescribed, more than 99% were for off-label uses.

"We anticipated there'd be a lot of off-label use," said senior researcher Amie Goodin, an assistant professor at the University of Florida College of Pharmacy.

Even so, she said, it was surprising to see the magnitude of that use.

And one-third of the time, patients prescribed gabapentin off-label were also on a medication that can depress the central nervous system.

That's a concern because in 2019, the U.S. Food and Drug Administration issued a warning about combining gabapentin with central nervous system (CNS) depressants, saying sedation and serious breathing problems can result. The warning was particularly aimed at people with risk factors for depressed breathing -- including the elderly and people with lung diseases like emphysema and chronic bronchitis.

"CNS depressant" is a broad term, Goodin said. It includes drugs ranging from antidepressants and anti-anxiety medications, to antihistamines, to muscle relaxants.

This study looked at prescriptions made between 2011 and 2016 -- before the FDA safety warning.

But, Goodin noted, at the time there was another reason for careful prescribing. Starting in 2008, gabapentin and other anti-seizure drugs were required to carry a warning about an association with increased risk of suicidal behavior.

"Gabapentin does have a reputation as a safe drug to try," Goodin said. "But there is some risk."

She recommended that people who are on the drug talk to their pharmacist about any safety concerns, especially if they are simultaneously taking other medications.

People will not necessarily know if they are taking a drug that is a CNS depressant, according to Bethany DiPaula, a professor at the University of Maryland School of Pharmacy.

Like Goodin, she noted that it is a broad category, and not every antidepressant or every anti-anxiety medication will fall into it.

DiPaula, who was not involved in the study, agreed that patients on gabapentin should take any questions to their pharmacist or the health care provider who prescribed it.

In general, DiPaula said, people should be sure all of their health care providers know which medications and supplements they are taking.

"And ideally," she said, "you should get all of your prescriptions from the same pharmacy."

For the study, Goodin and UF graduate student Brianna Costales used data from a federal survey that collects de-identified information on outpatient doctor visits nationwide.

Out of more than 200,000 patient records, just over 5,700 involved a gabapentin prescription. That corresponds to nearly 130 million visits nationally between 2011 and 2016.

The vast majority of those prescriptions were off-label, and most patients were also on other prescription drugs. In nearly one-third of cases, those additional medications included a CNS depressant.

Antidepressants were the most common type of CNS depressant, followed by opioid painkillers and benzodiazepines.

Of all office visits where off-label gabapentin was in the record, about 5% of patients had a depression diagnosis, and 3.5% had an anxiety disorder.

It's not clear, Goodin said, whether the gabapentin was prescribed specifically for those mental health disorders. There is a lot of crossover between pain and depression/anxiety, so it's possible the drug was prescribed for pain in at least some of those patients.

In general, Costales noted, there is little clinical trial evidence to support gabapentin for psychiatric conditions.

DiPaula said it is always wise for patients to make sure they understand exactly why a drug is being prescribed, and what the potential side effects are.

It's also important, she added, for patients to periodically review all of their medications with their provider, in part to talk about whether they are all still needed.

"De-prescribing" -- either lowering a drug dose or stopping it altogether -- is as important as adding new medications, DiPaula said.

The findings were published in the November issue of the journal Psychiatric Services.

More information

The U.S. Food and Drug Administration has more on gabapentin and CNS depressants.

SOURCES: Amie Goodin, PhD, MPP, assistant professor, College of Pharmacy, University of Florida, Gainesville; Brianna Costales, BS, doctoral student, College of Pharmacy, University of Florida; Bethany DiPaula, PharmD, professor, pharmacy practice and science, University of Maryland School of Pharmacy, Baltimore; Psychiatric Services, November 2021