611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net
Cancer
Resources
Basic InformationLatest News
New Hormonal Pill May Boost Outcomes for Older Breast Cancer PatientsBlack Women Have Triple the Odds for Lymphedema After Breast Cancer SurgeryWere Cancer Patients Neglected in U.S. COVID Vaccine Rollout?More Evidence That Pandemic Delayed Cancer DiagnosesDo Immune-Based Cancer Drugs Work Better in Men?Gene Test Spots Breast Cancer Patients Who Can Skip Post-Op ChemoOld Spice, Secret Antiperspirants Recalled Due to BenzeneClinical Trials Are Becoming More Diverse, But There's Still Work To DoFDA Approves Imaging Drug That Can Help Surgeons Spot Ovarian CancersA Routine Skin Check Could Save Your LifeWhat You Need to Know About Stomach CancerCOVID Booster Shot Helps Cancer PatientsLung Cancer Survival Continues to Improve, But Not for AllBreast Cancer Diagnosis Linked to Higher Odds for Dangerous A-FibDrug Used to Prevent Miscarriage May Raise Lifetime Cancer Risk in OffspringMore Evidence That COVID Vaccines Are Safe for Cancer PatientsExercise Helps Ease Arm, Shoulder Pain After Breast Cancer Surgery50 Years On, Real Progress in War Against CancerBiden Announces New Lung Health Program for U.S. VeteransTwo New Symptoms That Could Point to Pancreatic CancerBlack Men Less Likely to Get Follow-Up MRI When Test Suggests Prostate CancerUrine Test May Spot Aggressive Prostate CancerWill an Early-Stage Breast Cancer Spread? New Analysis Offers Some AnswersMore Lung Cancer Patients Are Surviving, ThrivingYounger Age Doesn't Boost Survival With Advanced Colon CancerShorter Course of Post-Op Radiation May Work Well for Prostate Cancer PatientsMany Blood Cancer Patients Get Little Protection From COVID VaccineToo Little Vitamin D Could Raise Colon Cancer Risk in Black WomenTargeted High-Dose Radiation Helps Fight Advanced Lung CancerCancer Costs U.S. Patients $21 Billion a YearWhy Are Cases of Pancreatic Cancer Rising in Young Women?Quit Smoking Before 45 & Wipe Out 87% of Lung Cancer RiskJust 5 Hours of Moderate Exercise a Week Cuts Your Cancer RiskWhen Cancer Strikes, Who's at Higher Risk for Suicide?Powell's COVID Death Despite Vaccination Shows Danger to Those With Weakened Immune SystemsTreating Depression Could Lengthen Lung Cancer Patients' LivesResearchers Find Better Way to Fight Breast Cancer That Has Spread to BrainCancer Care Costs U.S. $156 Billion Per Year; Drugs a Major FactorNearly Half of U.S. Breast Cancer Patients Use Pot or CBD; Many Don't Tell DoctorsAnti-Nausea Drug May Boost Survival for Some Cancer PatientsYour Free Cancer Screen Shows Trouble: What If You Can't Afford the Follow-Up?Access to Top Drugs Makes the Difference for Black Lung Cancer PatientsWhy Skin Cancer Checks Are Even More Important for Hispanic People1 in 7 Cancer Patients Worldwide Missed a Surgery Due to PandemicAI Helps Rule Out Cancer in Women With Dense BreastsExisting Drugs Could Treat Lung Cancer in NonsmokersColon Cancer Diagnoses Fell 40% in Pandemic, and That's Not Good NewsRacial Disparities Persist With Childhood CancersNew Tests for Colon, Prostate Cancer Show PromiseTough Choices: Chemo That Can Save Kids With Cancer Can Also Damage Hearing
LinksBook ReviewsSelf-Help Groups
Related Topics

Medical Disorders
Pain Management

Existing Drugs Could Treat Lung Cancer in Nonsmokers

HealthDay News
by Steven Reinberg
Updated: Oct 4th 2021

new article illustration

MONDAY, Oct. 4, 2021 (HealthDay News) -- There's some encouraging news for people who develop lung cancer even though they've never smoked.

Precision drugs already approved by the U.S. Food and Drug Administration can be used to treat 78% to 92% of their tumors, a new study reports. These precision drugs target specific mutations in tumors.

Most never-smokers' lung tumors have so-called driver mutations, specific mistakes in DNA that fuel tumor growth. A variety of drugs can block these mutations. Among smokers, only about half of lung cancers have these mutations, according to researchers.

Study author Dr. Ramaswamy Govindan said most lung cancer studies have focused on smokers, and even those that investigated the disease in people who have never used tobacco have not looked for "specific, actionable mutations" in a systematic way. An accurate tissue study is essential, he said.

"The patient must have a high-quality biopsy to make sure there is enough genetic material to identify key mutations," said Govindan, a professor of medicine at Washington University School of Medicine in St. Louis. "But testing these patients is critical. There is a high chance such patients will have an actionable mutation that we can go after with specific therapies."

His team analyzed lung tumors from 160 patients with lung cancer and no history of smoking. Researchers also compared data from these patients with data from smokers and never-smokers compiled by a pair of U.S. National Institutes of Health programs that characterized different types of cancer.

"Tobacco smoking leads to characteristic changes in the tumor cells, so we can look for telltale signs of smoking or signs of heavy exposure to secondhand smoke, for example," Govindan said in a university news release. "But very few of these patients' tumors showed those signs, so we could verify that this was truly a sample of lung cancer tumors in patients who had never smoked or had major exposure to tobacco smoke."

About 7% of these patients had evidence of mutations at birth that raised the risk of cancer -- either inherited or arising randomly, adding to the mystery of what causes lung cancer in people who have never used tobacco, the study found.

"There appears to be something unique about lung cancer in people who have never smoked," Govindan said. "We didn't find a major role for inherited mutations, and we don't see evidence of large numbers of mutations, which would suggest exposure to secondhand smoke."

He noted that about 60% of these tumors are found in females and 40% in males. While cancer in general is more common among men, lung cancer in people who never smoked is more common among women, for some unexplained reasons.

"The most important finding is that we identified actionable mutations in the vast majority of these patients -- between 80% and 90%," Govindan said. "Our study highlights the need to obtain high-quality tumor biopsies for clinical genomic testing in these patients, so we can identify the best targeted therapies for their individual tumors."

The findings were published Sept. 30 in the Journal of Clinical Oncology.

More information

For more about lung cancer and treatments, visit the American Cancer Society.


SOURCE: Washington University School of Medicine in St. Louis, news release, Sept. 30, 2021