611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net
Medical Disorders
Resources
Basic InformationLookupsLatest News
Meatpacking Plants Accounted for 334,000 U.S. COVID Cases: StudyDirty Air Could Raise COVID Risks for People With Asthma, COPD'Double-Masking' It? Proper Fit Is Crucial, Study FindsEvery American Adult Now Eligible for COVID-19 VaccineLive Near a 'Superfund' Site? Your Life Span Might Be ShorterHormone Treatments May Raise Blood Pressure in Transgender PeopleUnexplained Drop in Resting Heart Rate in Youth 'Not a Good Thing'Common MS Meds Might Be Less Effective in Black PatientsIs It Allergies or COVID? Expert Shows How to Tell the DifferenceMany Employees Have Mixed Feelings as Offices ReopenHalf of American Adults Have Now Gotten at Least One COVID Vaccine ShotWarmer Climate, More Pollen, Worse Allergies: How to Fight BackCycling During Dialysis? It Might Help PatientsPregnancy Raises the Risk for Kidney StonesU.S. Marines Study Finds Getting COVID Won't Protect Young People From ReinfectionKnow the Signs of Rare Blood Clot Linked With J & J Vaccine1 in 50 COVID Patients in ICU Will Develop a StrokeBooster Shots a Likely Reality for COVID-Vaccinated AmericansAHA News: The Link Between Structural Racism, High Blood Pressure and Black People's HealthMost Young Americans Eager to Get COVID Vaccine: PollRashes Can Occur After COVID Vaccine,  But Dermatologists Say 'Don't Worry'Even Before COVID, Many More People Died Early in U.S. Versus EuropeCOVID Plus 'Bleeding' Stroke Doubles a Patient's Death RiskLower Rates of COVID in States That Mandated Masks: StudyCDC Panel Says It Needs More Time to Study J&J Vaccine Clotting CasesOne Good Way to Help Beat COVID: ExerciseDiabetes Can Lead to Amputations, But Stem Cell Treatment Offers HopeResearch Shows Links Between Gum Disease and Alzheimer'sNo Rise in Global Suicide Rate in First Months of PandemicCloth Masks Do Make Workouts a Bit Tougher, Study FindsMany Kids Who Develop Severe COVID-Linked Syndrome Have Neurologic SymptomsBiden, Fauci Say Pause in J&J COVID Vaccine Is Sign That Safety Comes FirstAHA News: Straight Answers to Common Questions About COVID-19 VaccinesJ&J Vaccine 'Pause' Is Not Mandate Against the Shot, FDA SaysU.K. Variant Won't Trigger More Severe COVID, Studies FindNewborns Won't Get COVID Through Infected Mom's Breast Milk: StudyU.S. Health Agencies Call for Pause in J&J COVID Vaccine After 6 People Develop ClotsUrinary Incontinence Surgery Won't Raise a Woman's Cancer RiskCOVID Vaccines Trigger Protective Immune Response in Nursing Home Residents: StudyCOVID Vaccines Might Not Protect Certain Cancer PatientsHad Facial Fillers? What You Need to Know About COVID VaccinesAntibody Cocktail May Curb Infection in Unvaccinated Who Are Exposed to COVID-19Scientists Find Clues to Why AstraZeneca's Vaccine May Cause ClotsYou've Got Fungi in Your Lungs, and That's OKNon-Emergency Surgeries Are Rebounding, But Backlogs RemainPandemic Has Put Many Clinical Trials on HoldSupply of J&J COVID Vaccine to Drop 86 Percent Next WeekStressed, Exhausted: Frontline Workers Faced Big Mental Strain in PandemicNIH Starts Trial Looking at Rare Allergic Reactions to COVID VaccinesNot Just Keyboards: Many Types of Workers Can Develop Carpal Tunnel
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

NIH Starts Trial Looking at Rare Allergic Reactions to COVID Vaccines

HealthDay News
by Steven Reinberg
Updated: Apr 8th 2021

new article illustration

THURSDAY, April 8, 2021 (HealthDay News) -- A new clinical trial will investigate whether people who are highly allergic or have what's known as a mast cell disorder are at higher risk for a sudden allergic reaction to the Moderna or Pfizer COVID-19 vaccines.

"The public understandably has been concerned about reports of rare, severe allergic reactions to the Moderna and Pfizer-BioNTech COVID-19 vaccines," said Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases (NIAID).

"The information gathered during this trial will help doctors advise people who are highly allergic or have a mast cell disorder about the risks and benefits of receiving these two vaccines. However, for most people, the benefits of COVID-19 vaccination far outweigh the risks," Fauci said in a NIAID news release.

A systemic allergic reaction to a vaccine occurs in one or more parts of the body away from the injection site.

A mast cell disorder is caused by a type of white blood cell that is abnormal, overly active, or both. It puts a person at risk for life-threatening responses that look like allergic reactions.

Researchers will also look at the biological mechanism causing the reactions and whether there is a way to predict who is at most risk.

The Moderna and Pfizer COVID-19 vaccines have been given to millions of Americans. Most of the rare, severe reactions have happened to people with a history of allergies. A number of them had previously had a life-threatening allergic reaction called anaphylaxis, the researchers noted.

The new study will enroll 3,400 people between 18 and 69 years of age. Up to 35 allergy-research centers across the United States will take part, according to NIAID.

By design, about 60% of study participants must have a history of severe allergic reactions or have been diagnosed with a mast cell disorder. The rest will not.

Participants will be randomly assigned to receive either the Pfizer or Moderna shot, or a placebo followed by either vaccine.

About two-thirds of participants will be women, because severe allergic reactions to vaccines — and particularly to the Moderna and Pfizer COVID-19 vaccines — have happened in women, the researchers said.

The investigators will look at how many participants in each group have a systemic allergic reaction within 90 minutes after injection.

Results are expected late this summer.

More information

To learn more about COVID-19 vaccine safety, visit the U.S. Centers for Disease Control and Prevention.

SOURCE: U.S. National Institute of Allergy and Infectious Diseases, news release, April 7, 2021