611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net
Medical Disorders
Resources
Basic InformationLookupsLatest News
How Moving the Homeless to Hotels During the Pandemic Helps EveryoneA Vaccine Against UTIs? New Mouse Study Brings Shot CloserOpioid Use (and Overuse) for Knee Arthritis Takes Big Financial TollFormaldehyde in Hair Straighteners Prompts FDA WarningIt's Too Soon to Lift COVID Restrictions: FauciWith 3 COVID Vaccines Approved, Is There a 'Best' Shot?U.S. Hispanics at High Stroke Risk and Many Go Untreated: ReportCOVID Leaves Most Pro Athletes With No Lasting Heart Damage: StudyAmerican Indians Face the Highest Odds for StrokePerils of the Pandemic: Scooters, Cleansers and Button BatteriesModerna COVID Vaccine Can Sometimes Trigger Delayed Skin ReactionsMore Data Suggests New Coronavirus Variants Weaken Vaccines, TreatmentsAdd Sleep Woes to Long-Term Effects of ConcussionsCOVID Death Rates 10 Times Higher in Countries Where Most Are Overweight: ReportCould Taking a Swing at Golf Help Parkinson's Patients?Scientists Discover Why Blood Type May Matter for COVID InfectionNew Coronavirus Variant Out of Brazil Now in 5 U.S. StatesScientists Gain Insight Into Genetics of GlaucomaPatients With Sickle Cell Disease Often Overlooked for Life-Saving Kidney TransplantsDoes an Arthritis Drug Help Patients Battling Severe COVID? It Depends on the StudyNIH Halts Trial of Convalescent Plasma for Mild COVID-19COVID Vaccines for All American Adults by the End of May: BidenWhat You Need to Know About the New J&J COVID VaccineHow Climate Change Could Put More MS Patients in DangerFace Masks Won't Impede Your Breathing, Study ConfirmsSports Position Doesn't Affect Risk of Concussion-Linked CTE IllnessStrep Throat Doesn't Worsen Tourette But May Affect ADHD: StudyFauci Says U.S. Will Stay With Two Doses of Pfizer, Moderna VaccinesAHA News: Finally Getting Around to That Annual Physical? Here's What You Might FindStem Cell Injections Show Early Promise Against Spinal Cord InjuriesStudy Debunks Notion That Statin Meds Trigger Muscle AchesMore Than 87,000 Scientific Papers Already Published on COVID-19Underarm Lump After COVID Shot Is Likely Lymph Swelling, Not Breast Cancer, Experts SayVaccinating Oldest First for COVID Saves the Most Lives: StudyIf Protections Expire, COVID Patients Could Soon Face Big Medical BillsSharp Drop Seen in COVID Testing As New Cases PlateauFDA Approves Third COVID VaccineSpring Allergies Are Near, Here's What Works to Fight ThemRheumatoid Arthritis Meds May Help Fight Severe COVID-19Hair Salon Talk Can Spread COVID, But Face Shields Cut the DangerPandemic Is Hitting Hospitals Hard, Including Their Bottom LineExpert Panel Set to Consider Approval of J&J COVID VaccineIn Israel, Widespread Vaccination Slashes Severe COVID Cases in Older PatientsMental Health 'Epidemic' Threatens Communities of Color Amid COVID-19Masks Vital to Stopping COVID at Gyms, Studies ShowAs Climate Change Lengthens Allergy Season, Pollen Travels FartherVery Low COVID Infection Rate Among Dental Hygienists: StudyPandemic Is Adding to Teachers' Stress, and Quit RatesCOVID Cases, Deaths Plummet in Nursing Homes After Vaccine RolloutAHA News: What's Safe Once You've Had Your COVID-19 Vaccine?
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

Chronic Heartburn Raises Odds for Cancers of Larynx, Esophagus

HealthDay News
by By Amy Norton HealthDay Reporter
Updated: Feb 22nd 2021

new article illustration

MONDAY, Feb. 22, 2021 (HealthDay News) -- People with chronic heartburn may face increased risks of several rare types of cancer, a large U.S. government study shows.

Researchers found that among more than 490,000 Americans aged 50 and up, those with gastroesophageal reflux disease (GERD) had about twice the risk of developing cancers of the esophagus or larynx (also known as the voice box).

GERD, or acid reflux, occurs when stomach acids chronically escape into the esophagus, which is the muscular tube connecting the throat and the stomach. The most common symptom is heartburn.

The condition is exceedingly common, affecting an estimated 20% of Americans, according to the U.S. National Institutes of Health (NIH).

GERD has long been established as a risk factor for esophageal adenocarcinoma, which, in the United States, is the most common type of tumor arising in the esophagus.

The new study, published Feb. 22 in the journal Cancer, links GERD to a second type of esophageal cancer -- called squamous cell carcinoma -- as well as laryngeal cancer, which arises in the voice box.

Experts stressed that the absolute risk is low: The vast majority of people with GERD will never develop the cancers, all of which are fairly rare.

"Our findings should not alarm people diagnosed with GERD," said Christian Abnet, a researcher with the U.S. National Cancer Institute who led the study.

However, worldwide, squamous cell carcinoma is actually the much more common form of esophageal cancer, he noted, which is one reason why investigating any link to GERD is important.

Why would heartburn matter when it comes to cancer?

The esophagus is not used to the "caustic" substances dwelling in the stomach and small intestine, including acids and digestive enzymes, Abnet explained.

The longstanding theory around adenocarcinoma is that chronic exposure to those substances may damage the esophageal tissue in a way that occasionally leads to cancer.

In fact, the NIH says, about 10% to 15% of GERD patients have reflux severe enough to cause abnormalities in the esophageal lining, known as Barrett's esophagus. And of people with Barrett's, the risk of developing esophageal adenocarcinoma is about 0.5% per year.

It's possible, Abnet said, that similar mechanisms could also contribute to squamous cell carcinoma in the esophagus and to laryngeal cancer.

Whether treating GERD cuts those cancer risks "remains an open question," he said.

In the United States, he noted, the major drivers of the cancers studied here are smoking and heavy drinking.

"So avoiding those exposures is the most important preventive measure," Abnet said.

The findings are based on more than 490,600 U.S. adults who were between the ages of 50 and 71 at the outset. Nearly one-quarter had GERD.

Over about 16 years, more than 900 participants were diagnosed with esophageal adenocarcinoma, while about 300 developed the squamous cell form. Meanwhile, 876 people were diagnosed with laryngeal cancer.

On average, Abnet's team found, people with GERD were about twice as likely to develop any of the three cancers as people without GERD. That was after accounting for smoking, drinking habits and body weight.

Peter Campbell, scientific director of epidemiology research at the American Cancer Society, called the study "solid."

There are no standard screening tests for the cancers. But Campbell said people with GERD can be aware of the potential symptoms, which include: trouble swallowing, chest pain, hoarseness or voice changes, chronic cough and weight loss.

"It's important to note that having those signs or symptoms doesn't necessarily mean a person has cancer at one of these organ sites," Campbell stressed.

But, he said, anyone with GERD who notices those symptoms should talk to their doctor.

Similarly, Abnet said people with GERD symptoms should ask their doctor about lifestyle changes and/or medications that could help.

The lifestyle tactics for managing GERD include eating a healthy diet, quitting smoking and limiting alcohol, and shedding excess weight.

As it happens, Abnet noted, those same measures can help curb the risks of many different types of cancer.


More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has an overview of GERD.

SOURCES: Christian Abnet, PhD, MPH, division of cancer epidemiology and genetics, U.S. National Cancer Institute, Rockville, Md.; Peter Campbell, PhD, scientific director, epidemiology research, American Cancer Society, Atlanta; Cancer, Feb. 22, 2021, online