611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Health Sciences
Resources
Basic InformationLatest News
Staying Social Can Boost Healthy 'Gray Matter' in Aging BrainsDNA Analysis Might Reveal Melanoma RiskGenetics Might Explain Some Cases of Cerebral PalsyDiabetes Drug Metformin May Protect the Aging BrainNew Research Links Another Gene to Alzheimer's RiskYour Sex Affects Your Genes for Body Fat, Cancer, Birth WeightExperimental Drug Shows Promise Against ALSCould Gene Therapy Stem the Damage of Parkinson's?Genetic Research May Help Identify Causes of StillbirthBlood Test Heralds New Era in Alzheimer's DiagnosisMore Clues to the Genes Behind Hearing LossScientists Move Closer to Mapping Entire Human GenomeBlood Test May Reveal Concussion Severity With Accuracy of Spinal TapDeep Brain Stimulation May Slow Parkinson's, Study FindsStroke, Confusion: COVID-19 Often Impacts the Brain, Study ShowsYour Genes May Affect How You'll Heal If WoundedEven Without Concussion, Athletes' Brains Can Change After Head Jolts: StudyHealthDay In-Depth
The AI Revolution: For Patients, Promise and Challenges Ahead">HealthDay In-Depth
The AI Revolution: For Patients, Promise and Challenges Ahead
HealthDay In-Depth
The AI Revolution: Giving Docs a Diagnostic Assist">HealthDay In-Depth
The AI Revolution: Giving Docs a Diagnostic Assist
Blood Test Might Predict Worsening MSKeto Diet Might Change Your Gut in More Ways Than OneParkinson's Patient Improving After First-Ever Stem Cell TherapyKey Areas of the Brain Triggered in Recent Heart Attack SurvivorsFirst Good Evidence That Brain Hits 'Replay' While You SleepSome NFL Players May Be Misdiagnosed With Brain Disease: StudyGreenhouse Gases Bad for Your BrainTransplanted Skin Stem Cells Help Blind Mice See LightBrain Plaques Signal Alzheimer's Even Before Other Symptoms Emerge: Study'It's Like You Have a Hand Again': New Prosthetic Gets Closer to the Real ThingLosing a Spouse Could Speed Brain's DeclinePaddles Against Parkinson's: Ping Pong Might Ease SymptomsIn a First, Doctors Use Robotics to Treat Brain AneurysmSkiers Study Suggests Fitness May Stave Off Parkinson'sCRISPR Gene Editing Creates 'Designer' Immune Cells That Fight CancerGene Variant Ups Dementia Risk in Parkinson's Patients: StudyGene Variation May Protect Against Alzheimer's: StudyYoung-Onset Parkinson's May Start in the Womb, New Research SuggestsNew Gene Study Unravels Cancer's SecretsDoes Size Matter? Volume of Brain Area Not Always Tied to Memory, ThinkingGene Test Might Spot Soccer Players at High Risk for Brain TroubleSevere Deprivation in Childhood Has Lasting Impact on Brain SizeIn the Future, Could Exercise's Benefits Come in a Pill?Could Brain Scans Spot Children's Mood, Attention Problems Early?Brain Damage Changes Over Time in Boxers, MMA FightersSpecial 'Invisible' Dye Could Serve as Skin's Vaccination RecordCancer Drug Shows Promise for Parkinson's Patients'Smart' Contact Lenses Might Also Monitor Eye HealthCould Obesity Alter a Child's Brain Structure?Playing Sports Might Sharpen Your HearingAntarctic Study Shows Isolation, Monotony May Change the Human Brain
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

DNA Analysis Might Reveal Melanoma Risk

HealthDay News
by -- Steven Reinberg
Updated: Oct 8th 2020

new article illustration

THURSDAY, Oct. 8, 2020 (HealthDay News) -- DNA mutations in skin cells may signal a risk for melanoma long before it's visible to the eye, a new study suggests.

Exposure to sun damages skin and DNA, and this damage can be measured. Using a new method for analyzing DNA harm, researchers say they can estimate the risk of developing melanoma.

"It turns out that a multitude of individual cells in so-called normal skin are riddled with mutations associated with melanoma, which are a result of sun exposure," said researcher A. Hunter Shain, an assistant professor in the department of dermatology at the University of California, San Francisco.

"Melanoma is an endpoint most often seen only after decades of mutational damage, but some people are at greater risk than others. With the techniques we have developed, those who have the most accumulated mutations can be monitored more closely and can choose to better protect themselves from sun exposure," Shain said in a university news release.

Melanoma, which can be deadly, develops in skin cells called melanocytes. When melanocyte DNA is damaged, they can grow out of control.

The American Cancer Society says melanoma rates are rising. In 2020 about 100,000 people in the United States will be diagnosed with melanoma and nearly 7,000 will die.

For the study, the researchers sequenced DNA from 133 melanocytes. The cells came from two melanoma survivors and four cadavers of people who never had the skin cancer.

Melanocytes from the former cancer patients had more mutations, including melanoma-associated mutations, than skin from those who never had melanoma, the researchers found.

"Melanomas really can appear out of nowhere," Shain said. "We found out in this work that normal skin contains numerous melanocytes that already exhibit some of the mutations associated with cancer. Essentially, we found the precursors to the 70% of melanomas that do not arise from preexisting moles. Measuring mutations may be a good way to gauge the net effect of all these variables on melanoma risk."

The researchers noted that melanoma occurs more often on intermittently sun-exposed areas such as the back or thighs, compared with chronically exposed areas, such as the face. Consistent with this, Shain's team found more mutations on the back and limbs than on the head and neck.

"We anticipate that a streamlined, automated version of these methods will one day become widely available to gauge melanoma risk and could serve as the basis for cancer-screening recommendations," Shain said.

The report was published Oct. 7 in the journal Nature.

More information

For more on skin cancer, see the Skin Cancer Foundation.