611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net
Health Sciences
Resources
Basic InformationLatest News
Long-Term Outlook for Most With Serious Brain Injury Is Better Than ThoughtStroke Prevented His Speech, But Brain Implant Brought It BackWHO Calls for Global Registry of Human Genome EditingScientists Track Spirituality in the Human BrainNew Insights Into How Eating Disorders Alter the BrainGene Differences Could Have Black Patients Undergoing Unnecessary BiopsiesCRISPR Therapy Fights Rare Disease Where Protein Clogs OrgansNew Genetic Insights Into Cause of ALSDeep Brain Stimulation Therapy May Help Parkinson's Patients Long TermAmazon Tribe Could Hold Key to Health of Aging BrainsMan Blind for 40 Years Regains Some Sight Through Gene TherapyNew Insights Into Treating Mild Head Injuries'Ghosts and Guardian Angels': New Insights Into Parkinson's HallucinationsHigher Education Won't Help Preserve the Aging Brain: StudyScientists Create Embryos With Cells From Monkeys, Humans'Game of Thrones' Study Reveals the Power of Fiction on the MindScientists Create Human Tear Glands That Cry in the LabAHA News: How Grief Rewires the Brain and Can Affect Health – and What to Do About ItCould Taking a Swing at Golf Help Parkinson's Patients?Autopsy Study May Explain Why Some COVID Survivors Have 'Brain Fog'Gene Study Probes Origins of Addison's DiseaseCould a Common Prostate Drug Help Prevent Parkinson's?AHA News: Hormones Are Key in Brain Health Differences Between Men and WomenNerve Drug Might Curb Spinal Cord Damage, Mouse Study SuggestsIs There a 'Risk-Taking' Center in the Brain?AHA News: Dr. Dre Recovering From a Brain Aneurysm. What Is That?Can 2 Nutrients Lower Your Risk for Parkinson's?New Clues to How Cancers Originate in the BrainBrain May Age Faster After Spinal Cord InjuryScans Reveal How COVID-19 Can Harm the BrainWhat Loneliness Looks Like in the BrainNeurologists Much Tougher to Find in Rural AmericaCOVID-19 Survival Declines When Brain Affected: StudyAs Testing Costs Rise, Neurology Patients May Skip ScreeningGene Therapy Shows No Long-Term Harm in Animals: StudyCould Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise HopesCocoa Might Give Your Brain a Boost: StudyLockdown Loneliness Could Worsen Parkinson's SymptomsChildhood Lead Exposure Tied to Brain Changes in Middle AgeStaying Social Can Boost Healthy 'Gray Matter' in Aging BrainsDNA Analysis Might Reveal Melanoma RiskGenetics Might Explain Some Cases of Cerebral PalsyDiabetes Drug Metformin May Protect the Aging BrainNew Research Links Another Gene to Alzheimer's RiskYour Sex Affects Your Genes for Body Fat, Cancer, Birth WeightExperimental Drug Shows Promise Against ALSCould Gene Therapy Stem the Damage of Parkinson's?Genetic Research May Help Identify Causes of StillbirthBlood Test Heralds New Era in Alzheimer's DiagnosisDeep Brain Stimulation May Hold Promise in Alzheimer's
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

Genetics Might Explain Some Cases of Cerebral Palsy

HealthDay News
by -- Robert Preidt
Updated: Oct 1st 2020

new article illustration

THURSDAY, Oct. 1, 2020 (HealthDay News) -- Genetic problems cause about 14% of cerebral palsy cases, and many of the implicated genes control the wiring of brain circuits during early fetal development, new research shows.

The largest genetic study of cerebral palsy supports previous findings and provides "the strongest evidence to date that a significant portion of cerebral palsy cases can be linked to rare genetic mutations, and in doing so identified several key genetic pathways involved," said study co-senior author Dr. Michael Kruer. He's a neurogeneticist at Phoenix Children's Hospital and the University of Arizona College of Medicine.

The study was largely funded by the U.S. National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH).

"We hope this will give patients living with cerebral palsy and their loved ones a better understanding of the disorder, and doctors a clearer road map for diagnosing and treating them," Kruer said in an NIH news release.

The researchers first searched for spontaneous ("de novo") mutations in the genes of 250 families in the United States, China and Australia. These rare mutations are believed to occur when cells make mistakes copying their DNA as they multiply and divide.

Cerebral palsy patients had higher levels of potentially harmful de novo mutations than their parents, and about 12% of cerebral palsy cases in the study could be explained by de novo mutations, according to the study published Sept. 28 in the journal Nature Genetics.

This was especially true for cases that had no known cause and represented the majority (63%) of cases in the study.

About another 2% of cases in the study appeared to be linked to recessive, or weaker, versions of genes, which increased the estimate of cases that could be linked to genetic problems to 14%, as has been found in previous research.

Cerebral palsy affects about one in 323 U.S. children and causes permanent problems with movement and posture. The causes of many cases of cerebral palsy are unclear.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more on cerebral palsy.