611 W. Union Street
Benson, AZ 85602
(520) 586-0800

LaFrontera
member support line
1-520-279-5737
M-F 5pm-8pm
24/7 weekends/holidays

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Medical Disorders
Resources
Basic InformationLookupsLatest News
Many Americans Will Grieve Parents, Grandparents Lost to CoronavirusTouching Your Face Is a Coronavirus Danger: Tips to Help You StopBlack Americans Appear Most Vulnerable as U.S. Coronavirus Deaths Near 13,000More COVID-19 Tests Arrive, But Bottlenecks PersistAHA News: What Pregnant Women With High Blood Pressure Need to Know About COVID-19AHA News: Pandemic Puts Health Care Workers' Mental Health on the LineU.S. Study Finds COVID-19 Seldom Severe in KidsHigh-Tech Rings Are Tracking COVID-19 'Warning Signs'Beware of 'Media Overload' During Coronavirus Crisis, Experts SayYou're Wearing a Face Mask -- Are You Wearing It Correctly?What Material Is Best for Your DIY Face Mask? The Answer May Surprise YouAs U.S. Coronavirus Death Toll Nears 11,000, Signs Show Pandemic May Be PeakingWhy Will It Take So Long for a COVID-19 Vaccine?Pregnant Women Need to Guard Against CoronavirusCollege Students Feeling the Strain of Social DistancingHow One Patient's Battle With COVID-19 Changed U.S. Testing ProtocolsMission Possible: Tips for Safe Grocery Shopping During the PandemicTrials Begin for Potential COVID-19 Drug RemdesivirSchool Closures Will Force Many U.S. Health Care Workers to Stay HomeWith Coronavirus a Threat, Stop Wearing Contact LensesSome Steroid Meds May Raise Coronavirus RiskAmericans Got the Memo on Social Distancing, Poll ShowsCDC Urges All Americans to Wear Face Masks as Death Count RisesAHA News: Amid Coronavirus Crisis, Exercise Caution When Exercising OutdoorsAsthma, COPD Raise Odds for Severe COVID-19, Lung Experts WarnCoronavirus Hangs Around Even After Symptoms SubsideCan Food From an Infected Cook Give You COVID-19?Pregnant Women Need to Guard Against CoronavirusVitamin D Might Aid Seniors' Recovery From Hip Fracture: StudyWith 3D Printer, N.Y. Hospital Converts Sleep Apnea Machines Into VentilatorsAnother COVID-19 Vaccine Being Tested in Mice'Stay at Home' Orders Are Stressing U.S. Families, Survey ShowsAn Expert's Guide to Fighting Coronavirus StressHeart Patients Need to Be Wary of CoronavirusU.S. Coronavirus Cases Pass 200,000, as Jobless Claims Soar to 10 MillionIs Thyroid Hormone Dangerously Overprescribed in Older Patients?'Pink Eye' Often a Symptom of COVID-19, and Infection Via Tears PossibleMild COVID-19 Often Appears With Only Gastro Symptoms: StudyFDA Pulls Heartburn Drug Zantac From MarketCertain Health Conditions Up Risks for Severe COVID-19Parents, Arm Your Kids Against COVID-19 With Good Hand-Washing HabitsFDA Approves Malaria Drugs to Treat COVID-19, Despite Little Proof They Work'Fever Tracker' Suggests Social Distancing Is Already WorkingDon't Fall Prey to COVID-19 ScammersBeing Chained to Your Desk Might Harm Your ThyroidWhat You Should Know If Your Surgery Has Been Put on HoldAnother Coronavirus Health Threat: Too Few Asthma InhalersOdds of Hospitalization, Death With COVID-19 Rise Steadily With Age: StudyAHA News: Health Emergency? Don't Hesitate to Get HelpToo Many Patients, Too Few Ventilators: How U.S. Hospitals Cope With COVID-19
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

Cholesterol Drugs Might Help Curb 'High-Risk' Prostate Cancers

HealthDay News
by -- Robert Preidt
Updated: Feb 14th 2020

new article illustration

FRIDAY, Feb. 14, 2020 (HealthDay News) -- Drugs that many men with prostate cancer might already be taking -- cholesterol-lowering statins -- may help extend their survival if they have a "high-risk" form of the disease, new research suggests.

High-risk patients include men with high blood levels of prostate specific antigen (PSA) and a "Gleason score" of 8 or more. Gleason scores are a calculation used to gauge prognosis in prostate cancer. Men with a high Gleason score may develop difficult-to-treat cancers.

Prior research had suggested that statins and the diabetes drug metformin (often prescribed together) have anticancer properties. However, it hasn't been clear which of the two drugs is the bigger cancer-fighter, or whether either might help against high-risk prostate cancer.

To help answer those questions, a team led by Grace Lu-Yao of the Sidney Kimmel Cancer Center--Jefferson Health, in Philadelphia, tracked data on nearly 13,000 high-risk prostate cancer patients. All were diagnosed between 2007 and 2011.

The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival.

Men who took both statins and metformin had higher median survival (3.9 years) than those who took statins alone (3.6 years), metformin alone (3.1 years), or those who did not take either drug (3.1 years).

The study was published Feb. 8 in the journal Cancer Medicine.

"Both metformin and statins have been associated with longer life in prostate cancer patients, yet because they are commonly prescribed together, no study we know of has looked at these two medications separately," Lu-Yao said in a center news release. She's associate director of population science at the center.

"With respect to prostate mortality, metformin plus statin was associated with a 36% reduction in risk of death followed by statins alone," Lu-Yao added.

The study also found that those who took one of three types of statin -- atorvastatin, pravastatin or rosuvastatin -- had longer survival than those who did not take any statins. A similar benefit was not seen with a fourth statin, lovastatin.

Because prostate cancer thrives on testosterone, patients often receive treatments that reduce levels of male hormones (androgens). The new study found that among patients who received such therapies, those who took atorvastatin had a longer median time to prostate cancer progression than those who didn't take statins.

It's not clear why such effects were limited to atorvastatin, Lu-Yao said, but it appears to have the best "bioavailability" of the statin drugs and lingers longest in the body.

The research team believes that, based on the existing evidence, a clinical trial should be conducted to assess the effectiveness of statins and the combination of statins/metformin in extending survival of prostate cancer patients.

Two prostate cancer specialists unconnected to the new study agreed that the findings show promise.

"It appears that there may be a place in the treatment of prostate cancer for statins," said Dr. Elizabeth Kavaler, a urology specialist at Lenox Hill Hospital in New York City. "However, we are not yet at a point where we can use the data to direct patient care."

She believes testosterone may be key here. According to Kavaler, higher cholesterol levels promote higher levels of androgens, which in turn help encourage the growth of prostate cancer. Statins may help slow that process, Kavaler explained.

Dr. Manish Vira is vice chair for urologic research at The Arthur Smith Institute for Urology in New Hyde Park, N.Y. He agreed that the findings are encouraging, and noted that "a dozen actively recruiting clinical trials using either metformin or a statin in prostate cancer treatment" are already underway.

More information

The American Cancer Society has more on prostate cancer.