611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Health Sciences
Resources
Basic InformationLatest News
A Gene Kept One Woman From Developing Alzheimer's -- Could It Help Others?Could AI Beat Radiologists at Spotting Bleeds in the Brain?Pro Soccer Players More Likely to Develop Dementia: StudyExtinct Human Species Passed on Powerful Immune System GeneScientists ID Genes Tied to Left-HandednessScientists Creating Gene Map of Human 'Microbiome'New DNA Blood Test May Help Guide Breast Cancer TreatmentFootball Head Trauma Linked Again to Long-Term Brain DamageMore 'Buyer Beware' Warnings for Unregulated Stem Cell Clinics3-D Printers Might Someday Make Replacement HeartsOne Gene Change 2 Million Years Ago Left Humans Vulnerable to Heart AttackHow to Protect Your DNA for Big Health BenefitsBones Help Black People Keep Facial Aging at BayGene Test Might Someday Gauge Your Heart Attack RiskYour Gut Bacteria Could Affect Your Response to MedsIt's Never Too Late for New Brain CellsSensor-Laden Glove Helps Robotic Hands 'Feel' ObjectsAn Antibiotic Alternative? Using a Virus to Fight BacteriaBrain Sharpens the Hearing of the Blind, Study FindsMind-Reading Tech Could Bring 'Synthetic Speech' to Brain-Damaged PatientsCan Obesity Shrink Your Brain?Will You Get Fat? Genetic Test May TellMagnet 'Zap' to the Brain Might Jumpstart Aging MemoryWhy More Patients Are Surviving an AneurysmIsraeli Team Announces First 3D-Printed Heart Using Human CellsPoverty Could Leave Its Mark on GenesNFL Retirees Help Scientists Develop Early Test for Brain Condition CTEBrain 'Zap' Might Rejuvenate Aging MemoryLab-Grown Blood Vessels Could Be Big Medical AdvanceOnly Spoken Words Processed in Newly Discovered Brain RegionSmall Trial Provides New Hope Against Parkinson's DiseaseInsomnia May Be in Your Genes'Miracle' Young Blood Infusion Treatments Unproven, Potentially Harmful: FDAPossible Parkinson's 'Pandemic' Looms: ReportScience Puzzling Out Differences in Gut Bacteria Around the World'Mind-Reading' AI Turns Thoughts Into Spoken WordsEat What You Want and Still Stay Slim? Thank Your GenesGood News, Bad News on Levodopa for Parkinson's DiseaseNature or Nurture? Twins Study Helps Sort Out Genes' Role in DiseaseBeing Bullied May Alter the Teen BrainFDA Warns Companies on Dangerous, Unapproved Stem Cell TreatmentsGene Tweaking Prevented Obesity in MiceApproach That New Gene Testing Kit With CautionResearch on Almost 2,000 Brains Brings Insight Into Mental IllnessRestoring Hair Growth on Scarred Skin? Mouse Study Could Show the WayParkinson's Gene Therapy Wires New Brain CircuitsNext for Disabling Back Pain? New Discs From Patients' Own CellsSkin 'Glow' Test Might Someday Spot Disease Risk EarlyComputer-Brain Link Helps 'Locked In' People Chat, Surf WebDeep Brain Stimulation May Hold Promise in Alzheimer's
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

Extinct Human Species Passed on Powerful Immune System Gene

HealthDay News
by -- Steven Reinberg
Updated: Sep 23rd 2019

new article illustration

MONDAY, Sept. 23, 2019 (HealthDay News) -- You may have the extinct humans called Denisovans to thank for your adaptable immune system, Australian researchers suggest.

Denisovans were related to Neanderthals and interbred with modern humans about 50,000 years ago as modern humans left Africa for Papua New Guinea and Australia.

Modern humans got a gene variant from Denisovans that boosted immune reactions and inflammatory responses, including those that protect humans from disease-causing germs, the researchers reported.

"Previous research has found collections of gene variants from extinct human species that appear to have provided an advantage to humans living at high altitudes or to resist viruses, but have been unable to pinpoint which, if any, were actually functional," said senior study author Shane Grey. He is an associate professor who heads the Transplantation Immunology Laboratory at the Garvan Institute of Medical Research in Sydney, Australia.

"This study is the first to identify a single, functional variant, and suggests that it also had an evolutionary benefit on the human immune system," Grey added in an institute news release.

For the study, he and his colleagues analyzed genomes of families where one child had a severe and unusual autoimmune or inflammatory condition.

In four families, they found the same gene mutation, but this variant wasn't sufficient to cause inflammatory disease. But researchers also found that immune cells from these families produced a stronger inflammatory response than the immune cells from other individuals.

This particular mutation, called I207L, was common in families from Sydney and indigenous populations, such as those with Melanesian, Maori and Polynesian ancestry.

"The fact that this rare version of the gene was enriched in these populations, and displayed genetic signatures of positive selection, means it was almost certainly beneficial for human health," Grey said.

The mutation was also found in DNA from a 50,000-year-old finger bone of a Denisovan girl found in a cave in Siberia.

The variant, however, was absent in Neanderthal DNA from the same cave, which may mean that the gene variant came after Denisovans and Neanderthals split, about 400,000 years ago.

In experiments with mice, the I207L variant conferred a strong immune response to the Coxsackie virus strain, compared with a weak response in mice without the gene mutation, researchers found.

These findings indicate that the Denisovan variant and others are able to dial up the immune system to respond to different germs, the researchers said.

The report was published Sept. 18 in the journal Nature Immunology.

More information

For more on immune system, head to the U.S. National Institutes of Health.