611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Medical Disorders
Resources
Basic InformationLookupsLatest News
Mixing Marijuana With Opioids May Not Be Good for Mental HealthLarge Opioid Rx After Heart, Lung Surgery Often Leads to Misuse: StudyWhy Diet Sodas Aren't the Answer for Your Sugary Drink CravingsTB Cases Drop Among the Young, But Racial Disparities PersistCases of Lung Injury Tied to Vaping Keep RisingFish Oil Not a Magic Pill Against DiabetesFacing Up to a Lesser Known Form of Migraine PainDirty Air Is Deadly, Global Study ConfirmsSmoggy Air Might Contribute to Macular DegenerationMore Antibiotics, Higher Odds for Colon Cancer?The Merits of Physical TherapyVaping Constricts Blood Vessels, Raising Heart, Lung ConcernsWhen Does Heart Health Return to Normal After Quitting Smoking?New Antibiotic Approved for Community-Acquired Bacterial PneumoniaImplant Approved to Improve Symptoms in Advanced Heart Failure'No Quick Fix' for A-Fib, But Cardiologist Says You Can Help Prevent ItAHA News: Why Do Women Get Statins Less Frequently Than Men?'Dr. Google' Helps Some Patients Diagnose a Rare DiseaseHealth Tip: Recognizing a Staph InfectionIs Dairy Fat Different?CDC Recommends Catch-Up HPV Vaccination for Young AdultsHow to Relieve Dry, Irritated EyesPretomanid Approved for Treatment of Drug-Resistant TBAHA News: Tiring Easily May Warn of Future Heart TroubleAmerica's Obesity Epidemic May Mean Some Cancers Are Striking SoonerHeavy Smog as Bad as Pack-a-Day Smoking for LungsConcussed NFL Players Sidelined for Much Longer NowadaysHormone Therapy for Prostate Cancer Might Harm the Heart: StudyObesity and 'Spare Tire' Raise Hispanics' Odds for Early DeathAHA News: Protein Made During Long Workouts May Warn of Heart ProblemsHow to Help Your Heart Weather Extreme HeatHealth Threats Don't End for Some Sepsis SurvivorsHeat Waves Brought by Climate Change Could Prove Deadly for Kidney PatientsHealth Tip: Avoiding AnemiaAre You Still Putting Off Colon Cancer Screening?Tips for Preventing DiverticulitisFDA Reports More Seizures Among VapersKids Getting Too Many Opioids After TonsillectomyCan Major Surgeries Cause a Long-Term 'Brain Drain'?How Much Coffee Is Too Much for Migraine Sufferers?Steady Stream of Lesser Head Hits in Football Can Still Damage BrainDon't Sweat It: Hyperhydrosis Can Be TreatedFast-Food Joints on Your Way to Work? Your Waistline May WidenAdults Need Vaccines, TooHealth Tip: Managing Arthritis of the Hands'Selfies' Might Someday Track Your Blood PressureIn Heat Waves, Fans May Do More Harm Than GoodSmoking Creates Long-Lasting Risk for Clogged Leg ArteriesFootball Head Trauma Linked Again to Long-Term Brain DamageDrug Approved to Treat Tenosynovial Giant Cell Tumor
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

Scientists Develop an Antibiotic Alternative Against 'Superbugs'

HealthDay News
by By Dennis Thompson
HealthDay Reporter
Updated: May 29th 2019

new article illustration

WEDNESDAY, May 29, 2019 (HealthDay News) -- "Superbugs" strike fear in the hearts of scientists who are racing to find new drugs to fight these dangerous infections, but British researchers now report they have developed a compound that could battle these antibiotic-resistant bacteria in an entirely new way.

The compound, a metal complex based on the element ruthenium, "works by binding to the cell wall of bacteria and disrupting so much the bacterial cells eventually burst open," explained senior researcher Jim Thomas. He is a professor of bioinorganic chemistry at the University of Sheffield, in England.

"We have found a completely new kind of therapeutic lead to treat infections that are top of the World Health Organization's 'Priority Pathogens List' of bacteria that, due to complete resistance to current [antibiotics], urgently need new treatments," Thomas said.

The drug had been investigated to fight cancer, but the researchers felt it might also have promise as an antibacterial agent, he explained.

"So we slightly tweaked one of our anticancer drug leads so that it would be preferentially taken up by bacteria rather than human cells," Thomas said.

Lab tests showed that the compound is "pretty effective," he said.

"We have tested it against a number of bacteria, including pathogenic, multidrug-resistant forms," Thomas said. "We found it is as potent as current antibiotics, but retains its potency in the hard-to-treat, drug-resistant forms."

The compound also carries a plus for researchers -- it's luminescent, glowing when exposed to light, he added.

"We can directly image their uptake into bacteria and watch how they are working within the cell," Thomas explained.

The potential new drug is particularly effective against Gram-negative bacteria strains, which are more difficult to treat with antibiotics because the cell walls of the bacteria are tougher to penetrate, the study authors said.

For example, the drug killed E. coli in lab tests, the researchers found.

It also appears to be safe in animals.

"We have done some initial animal model work using Wax moth larvae and non-cancerous human cell cultures," Thomas said. "These studies reveal that even at concentrations that are hundreds of times higher than those that kill bacteria, the compound is nontoxic to our models. We will have to do further studies in mice and other animals before this progresses to humans."

This is another of several lines of research into new ways to combat bacteria that are becoming more resistant to antibiotics.

Each year, at least 2 million Americans develop an antibiotic-resistant infection and at least 23,000 die, according to the U.S. Centers for Disease Control and Prevention.

Americans have become acutely aware of the threat. A recent poll sponsored by the Infectious Diseases Society of America found that 65% of Americans believe antibiotic resistance is a public health problem, and 81% are worried that such resistance will make infections difficult to treat or even deadly.

Dr. Amesh Adalja is a senior scholar with the Johns Hopkins Center for Health Security, in Baltimore. "As the march of antimicrobial resistance continues and physicians are increasingly faced with little to no options in treating serious life-threatening infections, it is essential to heighten the search for new tools and move beyond traditional antibiotics," he said.

"The new compounds described in this work are unique and have multiple mechanisms of action increasing the threshold for bacteria to acquire resistance," Adalja continued. "It will be important to develop this line of investigation to see if it can yield a drug with therapeutic value."

The new study was published May 28 in the journal ACS Nano.

More information

The U.S. Centers for Disease Control and Prevention has more about antibiotic resistance.