611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Medical Disorders
Resources
Basic InformationLookupsLatest News
AHA News: Emphysema May Raise Risk of Ruptured AneurysmsNew Facial Bone Might Someday Be Grown From the Patient's RibWhat Works Best for Women Struggling With a Leaky Bladder?Your Apple Watch Might Help Spot a Dangerous Irregular HeartbeatDocs Back Away From Low-Dose Aspirin for Heart Attack PreventionAHA News: Overweight Kids at Higher Risk for Blood Clots as AdultsEbola Survivors Continue to Suffer Years After RecoveryFewer Boys Are Suffering Head Injuries, But Rate Rises for GirlsAHA News: Black Woman in Their 50s Face Especially High Stroke RiskNew Drug Could Help Those With Tough-to-Treat CholesterolWhen Can Kids Return to Play After a Concussion?Need to Be Vaccinated? Try Your Local PharmacyOne-Third of U.S. Kids Have Back Pain, Study SaysBlacks, Hispanics Bear Burden of Air Pollution: StudyChickens Help Scientists Pinpoint Origin of Rare, Deadly VirusDry Eye and Migraines Might Be Linked: StudySkin Fungi May Be Tied to Bowel DiseaseYo-Yo Dieting Can Take a Toll on Your HeartAHA News: Opioid Meds Pose Danger to Kidney Disease PatientsHealth Tip: UTI Warning SignsStaph Infections Drop, but Levels Still Worry U.S. Health OfficialsTreatment May Allow Allergic Kids to Eat Eggs Safely: StudyAcne Drug Accutane May Not Depress Mood After AllHealth Tip: Preventing Carpal TunnelMajor Flooding Can Bring Skin Infection DangersSmall Trial Provides New Hope Against Parkinson's DiseaseIs Your Hand Pain Arthritis, Carpal Tunnel or Something Else?California Parents Are Getting Around Vaccine Law, Fueling Measles OutbreaksSeniors With UTIs Need Antibiotics ASAP, Study SaysWhy Do Some Kids With Eczema Develop Food Allergies?High-Fiber Diet May Help Gut 'Microbiome' Battle MelanomaTick Bites More Likely to Cause Red Meat Allergy Than ThoughtWalking, Not Riding, Boosts Health in Golfers With Knee WoesIs At-Home Stool Test a Viable Alternative to Colonoscopy?After Peanut Allergy Rx, Eating Small Bits of Peanut Might Help: StudyA Hard Look at Smoking's Effect on VisionPeanut Allergy Patch Shows Middling Results in TrialToxins in Home Furnishings Can Be Passed on to KidsKratom-Related Poisonings Are Soaring, Study FindsFDA Aims to Strengthen Sunscreen RulesBrain Condition CTE Seen in H.S. Football Players: StudyPregnant Women Should Delay Gallbladder Surgery, Study FindsGut Microbes May Help Drive Lupus, Study FindsMost Hip, Knee Replacements Last Decades, Study FindsAHA News: Living Near Convenience Stores Could Raise Risk of Artery-Clogging ConditionPossible Parkinson's 'Pandemic' Looms: Report'Apple-Shaped' Body? 'Pear-Shaped'? Your Genes May TellProtect Your Aging Eyes From Macular DegenerationKidney Failure Patients Face Higher Risk of Cancer DeathHow Inactivity and Junk Food Can Harm Your Brain
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

Skin Fungi May Be Tied to Bowel Disease

HealthDay News
by -- Robert Preidt
Updated: Mar 8th 2019

new article illustration

FRIDAY, March 8, 2019 (HealthDay News) -- Crohn's disease involves inflammation of the digestive tract. But new research into its causes is focusing on fungi commonly found on the skin.

These microscopic fungi, called Malassezia restricta, are linked to dandruff. They're found in oily skin and scalp follicles, but they also end up in the gut. However, it's not known how they get there or what they do.

The fungi may worsen intestinal disorders such as Crohn's disease -- a type of inflammatory bowel disease -- in patients with a certain genetic makeup, according to the study. Crohn's symptoms can include diarrhea, stomach cramping and weight loss.

The study results were published March 5 in the journal Cell Host & Microbe.

"We were surprised to find that Malassezia restricta was more common on intestinal tissue surfaces in Crohn's disease patients than in healthy people," said study co-author David Underhill. He is chair of inflammatory bowel disease at Cedars-Sinai Medical Center in Los Angeles.

"Further, the presence of Malassezia was linked to a common variation in a gene known to be important for immunity to fungi -- a genetic signature more common in patients with Crohn's disease than the healthy population," Underhill said in a journal news release.

Changes in intestinal fungi such as M. restricta -- and how an individual body responds to these fungi -- may help worsen symptoms in some patients with Crohn's disease, said study co-author Jose Limon, a Cedars-Sinai research team member.

The researchers initially found that in mice, the presence of M. restricta worsened colitis, a type of intestinal inflammatory disease.

Further investigation showed that levels of M. restricta were elevated in Crohn's patients who had a genetic variation known as the IBD CARD9 risk allele. This boosts the ability of immune cells to pump out inflammatory signaling molecules in response to M. restricta.

"The data so far do not suggest that the presence of Malassezia in the gut is an inherently bad thing. We found it in some healthy people, and in mice it does not seem to cause disease in the gut by itself," Underhill said. "However, if there is some intestinal inflammation, Malassezia seems to make it worse."

The next step in this research includes determining whether eliminating M. restricta from the intestine in this group of Crohn's patients eases their symptoms.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more on Crohn's disease.