611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Medical Disorders
Resources
Basic InformationLookupsLatest News
Pool Chemicals Harm Thousands Every SummerAre Diets High in Processed Foods a Recipe for Obesity?Lupus Takes Bigger Toll on Longevity for BlacksScientists Spot Unexpected Player in FibromyalgiaAnthrax Is a Risk on Every ContinentAHA News: More Clues to the Genetics Behind an Inherited Cholesterol DisorderSuspect Your Child Has an Ear Infection? There May Soon Be an App for ThatLyme Disease Now a Threat in City Parks Health Tip: Treating a Charley HorseMore Back-to-Back Heat Waves Will Come With Climate ChangeParents, Here's How to Protect Your Child During Measles OutbreaksAHA News: Dangerous Blood Clots May Be the Latest Risk From 'Bad' CholesterolAre You Running Short on Iron?1 in 4 American Workers Struggles With Back PainInjured Lungs Can Be Regenerated for Transplant: StudyKeeping Your Summer Fun on Sound FootingMore Active Lupus Linked to Childhood EventsSigns of Rheumatoid Arthritis Can Show Up Long Before DiagnosisSummer Is Tough for Asthma SufferersHepatitis A Infections Soaring: CDCIs the County You Call Home a Potential Measles Hotspot?'Zap' Ear Clip May Ease A-FibTake Steps to Prevent a StrokeDoes Removing Your Appendix Put You at Risk for Parkinson's?Potentially Blinding Shingles of the Eye on the RisePsoriasis, Mental Ills Can Go Hand in HandAfter Concussions, Some Ex-Athletes Show Key Marker for Brain Disease: StudyWindow for Safe Use of Clot-Buster Widens for Stroke PatientsAn Antibiotic Alternative? Using a Virus to Fight BacteriaDo Adults Need a Measles Booster Shot?Military Tourniquets Might Save Kids' Lives During School ShootingsWell Water's Spillover Effect: Heart Damage?AHA News: Helping Asian-Americans Fight Their Hidden Heart RisksSunscreen Chemicals Enter Bloodstream at Potentially Unsafe Levels: Study'Ringing in the Ears' May Drive Some to the Brink of SuicideBlood Test Might Diagnose Chronic Fatigue SyndromeAsthma Inhalers Incorrectly Used by Most Kids in StudyDevice Helps Doctors Select Lungs for TransplantBenlysta Approved for Children With LupusIn a World First, Drone Delivers Kidney for TransplantHigh Measles Rates Mean Kids, Adults Need Proper Vaccination: CDCParents, Protect Your Kids as Measles Outbreaks SpreadWork Stress, Poor Sleep, High Blood Pressure a Deadly TrioFor Obese People, Commuting by Car Can Be a Killer: StudyHealth Tip: Tick RemovalHalf of Older Dialysis Patients Die Within a Year, Study FindsIs Peanut Allergy 'Immunotherapy' Causing More Harm Than Good?Long-Term Antibiotic Use May Up Women's Odds for Heart TroubleSalmonella Outbreak Tied to Pre-Cut Melons Expands to More Than 100 CasesAs U.S. Measles Cases Hit New High, Experts Warn the Disease Can Be Deadly
Questions and AnswersLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

High-Fiber Diet May Help Gut 'Microbiome' Battle Melanoma

HealthDay News
by By Serena GordonHealthDay Reporter
Updated: Feb 27th 2019

new article illustration

WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- A healthy diet may trigger a better response to a certain kind of melanoma treatment.

How?

New research suggests that a diet that's full of fiber appears to lead to more diverse intestinal bacteria (microbiome). In turn, a thriving gut microbiome is linked to a stronger response to an immune therapy for the aggressive skin cancer.

"We found that patients eating a high-fiber diet at the start of therapy were about five times more likely to respond to the anti-PD-1 immunotherapy," said study author Christine Spencer. She's a research scientist with the Parker Institute for Cancer Immunotherapy in San Francisco.

Anti-PD-1 immunotherapy helps the immune system recognize cancer cells as dangerous cells that need to be destroyed, according to the American Cancer Society (ACS). The cancer drugs Keytruda and Opdivo are examples of this type of immunotherapy.

Melanoma is a type of skin cancer. It only accounts for about 1 percent of all skin cancers, but is responsible for most skin cancer deaths, the ACS says.

Several recent studies have suggested that a healthy and diverse gut microbiome might improve the response to melanoma immunotherapy treatments, the researchers said. What wasn't known was how certain diets might improve the microbiome and boost the response to melanoma treatment.

To see what difference diet might make, the researchers collected fecal samples from more than 100 people being treated for melanoma at the MD Anderson Cancer Center, in Houston. With these samples, the researchers could learn what types of bacteria people had in their gut microbiome, as well as how diverse the bacteria in the microbiome were.

The investigators then compared these findings to a previously completed diet/supplement survey to see what type of diet was linked to a more robust gut microbiome.

The findings showed that a high-fiber diet -- one full of vegetables, fruits and whole grains -- was associated with the types of bacteria that had already been linked to a better response to anti-PD-1 therapy.

The researchers also noted that about 40 percent of the people in the study were taking a probiotic supplement. Probiotics contain live bacteria believed to be helpful to maintaining the balance of the microbiome. However, the researchers found that probiotic use was actually linked to lower diversity of the gut microbiome.

And, a lower diversity of the microbiome has been linked to a poorer response to melanoma immunotherapy, the researchers noted.

The study team also looked at a group of almost 50 patients who had complete information on diet and gut microbiome, and found that those on a high-fiber diet were about five times more likely to respond to anti-PD-1 treatment than people eating a low-fiber diet.

Dr. Marcel van den Brink, head of the division of hematologic malignancies at Memorial Sloan Kettering Cancer Center in New York City, said, "This study found a high-fiber diet would lead to better diversity in the gut flora, and greater diversity gave you better outcomes," at least for anti-PD-1 immunotherapy.

"In clinical medicine, we do a great job of monitoring a lot of parameters. But when it comes to monitoring what people eat and effects of diet, we're doing a lousy job," he added.

"Patients and family members ask about diet, and we say, 'Just eat healthy,' and we don't have much more specific guidelines," van den Brink explained.

"So, these types of studies are intriguing. Diet may work in a collaborative way with immune therapy. But, we're not there yet. This was a small study. The research is early," he noted.

Still, van den Brink said that he suspected -- from this study and others, including his own research on the microbiome in blood cancers -- that the gut microbiome likely influences the immune system throughout the body, and he thinks the microbiome "will be relevant for most, if not all, immune therapies in cancer."

Spencer said hers was the first study on diet and melanoma immunotherapy. She agreed more research is needed before doctors can make specific recommendations on diet.

The findings were scheduled for presentation at the American Association for Cancer Research annual meeting, in Atlanta, March 29 to April 3. Research presented at meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

Learn more about melanoma from the American Cancer Society.