611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Health Sciences
Resources
Basic InformationLatest News
Scientists ID Genes Tied to Left-HandednessScientists Creating Gene Map of Human 'Microbiome'New DNA Blood Test May Help Guide Breast Cancer TreatmentFootball Head Trauma Linked Again to Long-Term Brain DamageMore 'Buyer Beware' Warnings for Unregulated Stem Cell Clinics3-D Printers Might Someday Make Replacement HeartsOne Gene Change 2 Million Years Ago Left Humans Vulnerable to Heart AttackHow to Protect Your DNA for Big Health BenefitsBones Help Black People Keep Facial Aging at BayGene Test Might Someday Gauge Your Heart Attack RiskYour Gut Bacteria Could Affect Your Response to MedsIt's Never Too Late for New Brain CellsSensor-Laden Glove Helps Robotic Hands 'Feel' ObjectsAn Antibiotic Alternative? Using a Virus to Fight BacteriaBrain Sharpens the Hearing of the Blind, Study FindsMind-Reading Tech Could Bring 'Synthetic Speech' to Brain-Damaged PatientsCan Obesity Shrink Your Brain?Will You Get Fat? Genetic Test May TellMagnet 'Zap' to the Brain Might Jumpstart Aging MemoryWhy More Patients Are Surviving an AneurysmIsraeli Team Announces First 3D-Printed Heart Using Human CellsPoverty Could Leave Its Mark on GenesNFL Retirees Help Scientists Develop Early Test for Brain Condition CTEBrain 'Zap' Might Rejuvenate Aging MemoryLab-Grown Blood Vessels Could Be Big Medical AdvanceOnly Spoken Words Processed in Newly Discovered Brain RegionSmall Trial Provides New Hope Against Parkinson's DiseaseInsomnia May Be in Your Genes'Miracle' Young Blood Infusion Treatments Unproven, Potentially Harmful: FDAPossible Parkinson's 'Pandemic' Looms: ReportScience Puzzling Out Differences in Gut Bacteria Around the World'Mind-Reading' AI Turns Thoughts Into Spoken WordsEat What You Want and Still Stay Slim? Thank Your GenesGood News, Bad News on Levodopa for Parkinson's DiseaseNature or Nurture? Twins Study Helps Sort Out Genes' Role in DiseaseBeing Bullied May Alter the Teen BrainFDA Warns Companies on Dangerous, Unapproved Stem Cell TreatmentsGene Tweaking Prevented Obesity in MiceApproach That New Gene Testing Kit With CautionResearch on Almost 2,000 Brains Brings Insight Into Mental IllnessRestoring Hair Growth on Scarred Skin? Mouse Study Could Show the WayParkinson's Gene Therapy Wires New Brain CircuitsNext for Disabling Back Pain? New Discs From Patients' Own CellsSkin 'Glow' Test Might Someday Spot Disease Risk EarlyComputer-Brain Link Helps 'Locked In' People Chat, Surf WebCould a Natural Protein Help Fight Obesity?Blood Test May One Day Help Track Concussion RecoveryThe Bigger the Brain, the Bigger the Tumor Risk?Gene Therapy for Parkinson's Symptoms Shows PromiseCould Same-Sex Couples Have Babies With Shared DNA? Study Hints It's Possible
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

Gene Tweaking Prevented Obesity in Mice

HealthDay News
by -- Robert Preidt
Updated: Dec 14th 2018

new article illustration

FRIDAY, Dec. 14, 2018 (HealthDay News) -- A modified version of the CRISPR gene-editing technique could help fight obesity without having to alter any genes, a new study in mice suggests.

CRISPR, an acronym for a family of DNA sequences, generally involves cutting or editing DNA to correct genetic defects that cause disease.

This new technique boosts the activity of certain genes and prevented severe obesity in mice genetically altered to be susceptible to extreme weight gain.

No editing changes were made to any genes to achieve long-lasting weight control in the mice, according to the researchers at the University of California, San Francisco (UCSF).

"Though this particular study focused on obesity, we believe our system could be applied to any situation in which having only one functional copy of a gene leads to disease," said study senior author Nadav Ahituv, a professor of bioengineering and therapeutic sciences at UCSF.

"Our method demonstrates tremendous therapeutic potential for numerous diseases, and we show that we can achieve these benefits without making any edits to the genome," Ahituv added in a university news release.

However, animal research does not always pan out in humans.

The technology used in the study is called CRISPRa ("a" for activation) and was developed at UCSF. Unlike conventional CRISPR, this approach does not make changes to genes, but instead increases the activity of targeted genes.

In this case, the researchers used CRISPRa to amplify the activity of two genes -- SIM1 and MC4R -- that are important in regulating hunger and feeling full.

When both copies of these genes are functioning, people are able to control their food intake. But mutations can result in one copy being nonfunctional, and a single working copy is not sufficient to control appetite.

The mice in the study had only one functional copy of each gene, but CRISPRa increased the activity of the single genes to a level comparable to that of two working genes.

"The results were dramatic. Mice that were missing one copy of the SIM1 gene received the CRISPRa injections at 4 weeks of age and maintained a healthy body weight like normal mice. Mice that didn't receive CRISPRa injections couldn't stop eating," said study author Navneet Matharu, a researcher in Ahituv's UCSF lab.

The CRISPRa-treated mice were 30 to 40 percent lighter than untreated mice, and a single CRISPRa treatment maintained a healthy weight in mice for the entire 10 months they were monitored.

"These results demonstrate that CRISPRa can be used to up the dosage of genes in diseases that result from a missing copy, providing a potential cure for certain forms of obesity as well as hundreds of other diseases," Matharu added.

The study was published Dec. 13 in the journal Science.

More information

The U.S. Centers for Disease Control and Prevention has more on overweight and obesity.