611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

AzCH Nurse Assist Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Mental Disorders
Resources
Basic InformationLookupsLatest NewsQuestions and AnswersLinksBook Reviews
Related Topics

Anxiety Disorders
Bipolar Disorder
Depression: Depression & Related Conditions
Schizophrenia
Eating Disorders

Is Evolution of the Human Brain to Blame for Some Mental Disorders?

HealthDay News
by -- Robert Preidt
Updated: Aug 9th 2018

new article illustration

THURSDAY, Aug. 9, 2018 (HealthDay News) -- Evolutionary changes in the human brain may be responsible for psychiatric illnesses such as schizophrenia and bipolar disorder, new research suggests.

The researchers identified long, noncoding stretches of DNA (called "repeat arrays") in a gene that governs calcium transport in the brain. Their findings were published Aug. 9 in the American Journal of Human Genetics.

"Changes in the structure and sequence of these nucleotide arrays likely contributed to changes in CACNA1C function during human evolution and may modulate neuropsychiatric disease risk in modern human populations," senior author David Kingsley said in a journal news release. Kingsley is a professor of developmental biology at Stanford University in California.

The study authors suggested that the findings could lead to improved treatment for patients with schizophrenia and bipolar disorder, which affect about 3 percent of people worldwide.

Classifying patients based on their repeat arrays may help identify those most likely to respond to current calcium channel drugs, which so far have produced mixed results, Kingsley said.

He added that more research is needed to determine whether patients with a genetic variation of CACNA1C have too much or too little calcium channel activity.

The repeat arrays in the CACNA1C gene occur only in humans. Kingsley said that suggests the arrays may have given humans an evolutionary advantage, even if they increased the risk of conditions such as schizophrenia and bipolar disorder.

More information

The U.S. National Institute of Mental Health has more on schizophrenia.