611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line

NurseWise 24-Hour Crisis Line


611 W. Union Street
Benson, AZ 85602
(520) 586-0800

NurseWise 24-Hr Crisis Line


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...

Medical Disorders
Basic InformationLookupsLatest News
Excess Weight May Raise Rosacea RiskDecline in Antibiotic Use in Livestock Isn't Enough, Critics SayCould a Hot Cup of Tea Preserve Your Vision?Breathing Retraining Beneficial in Patients With AsthmaZika Babies Facing Increasing Health Problems With AgeHealth Tip: Dental Association Supports Fluoridated WaterAnother Legacy of Terror Attacks: MigrainesRain May Not Cause Achy Joints After AllDisrupted Sleep Linked to Increased Amyloid-β ProductionAtherosclerosis ID'd in Many Without CV Risk FactorsArtificial Intelligence Promising for CA, Retinopathy DiagnosesFirst Drug Approved for Rare Condition That Inflames Blood VesselsProtecting Your Health From Wildfire SmokeHealth Tip: Recognize Warning Signs of HypothermiaNew Hope for Kids With Multiple Food AllergiesFew Patients, Providers Discuss Costs of Glaucoma Medicationsβ-Cell Sensitivity to Glucose Impaired After Gastric BypassHow to Perk Up the Holidays for Hospital PatientsVigorous Exercise May Help Slow Parkinson's DiseaseIf Mom Has Rheumatoid Arthritis, Baby May Develop It, TooNew Gene Therapy May Be Cure for 'Bubble Boy' DiseaseAnother Gene Therapy Breakthrough Against HemophiliaPrenatal Sugar Intake May Increase Asthma Risk in OffspringObesity May Be Tied to Higher Rosacea Risk in WomenGot Scabies? Here's What to DoAre Women With Parkinson's at a Disadvantage?Bariatric Surgery Alters Liver Fatty Acid MetabolismORBIT Bleeding Risk Score Performs Best in A-FibHealth Tip: Prevent the Spread of NorovirusAre Good Kidneys Going to Waste?Metabolic Risk Factors Linked to Severe Liver DiseaseImpaired White Matter Integrity for Depression in Parkinson'sHave Eczema? No Need for Bleach Baths, Study SuggestsPowerful Clot-Busting Drugs Not Useful After Leg Blockages: StudyComing Soon: A Gel That Could Help Save Soldiers' EyesGene Therapy May Allow Hemophilia Patients to Go Without MedsThyroidectomy-Specific Quality Improvement Measures ID'dPatients OK With Fewer Opioids After Gallbladder SurgeryShhhh! Patients Are SleepingDiagnostic Mutations ID'd in Chronic Kidney Disease PatientsAntithrombotics Deemed Safe in Carpal Tunnel Release SurgeryLink Between Diabetes, Antibiotic Use Called Into QuestionHealth Tip: Diagnosing PneumoniaNoisy Commutes Could Cause Long-Lasting DamageThe Buzz on How Flies Spread DiseaseRisk of Surgical Complications Up for Overlapping Hip SurgeryOral Microbiome Composition Linked to Esophageal Cancer RiskSmartphone Pics Help Docs ID Kids' Skin ConditionEven Non-Heart Surgery May Harm Your HeartCan Scrotal Vein Condition Hike Heart Risks?
Questions and AnswersLinksBook Reviews
Related Topics

Men's Health
Women's Health

How Zika Virus Went From Mild to Devastating

HealthDay News
by By Dennis Thompson
HealthDay Reporter
Updated: Sep 28th 2017

new article illustration

THURSDAY, Sept. 28, 2017 (HealthDay News) -- A single genetic mutation just a few years back gave the Zika virus the ability to cause severe neurological birth defects like microcephaly, a new study in mice suggests.

Scientists have known about the Zika virus since 1947, when it was discovered in a monkey from the Zika Forest in Uganda. At that point, it was only linked to mild symptoms.

It wasn't until the Zika epidemic of 2015 in Central and South America that Zika became known as a cause of microcephaly, a devastating condition in which a newborn's brain and skull are severely underdeveloped.

How did that happen?

One particular genetic change, which likely occurred in 2013, boosted Zika's ability to damage the neural stem cells that serve as building blocks for a fetus' developing brain, Chinese researchers report.

"The evidence suggests this particular mutation somehow increased the ability of the virus to get into these neural progenitor cells," said Dr. Joseph McCormick, regional dean at the University of Texas School of Public Health in Brownsville. McCormick wasn't involved in the new study.

This discovery is disturbing because it suggests that the virus could have more unwelcome surprises in store for humanity, said Michael Osterholm, director of the University of Minnesota's Center for Infectious Disease Research and Policy.

"The mutation that potentially caused this health outcome in humans is occurring in a virus where additional mutations could still occur, which could bring us other new health challenges," said Osterholm, who had no role in the research.

Zika is transmitted primarily by infected mosquitoes. It can also be spread by having sex with an infected person.

The Chinese team, whose first author is Ling Yuan of the Chinese Academy of Sciences in Beijing, compared three current Zika strains against an older strain isolated in Cambodia in 2010.

The three current strains killed all lab mice exposed to it, producing a series of neurological symptoms. On the other hand, the 2010 strain only killed about 17 percent of mice.

Comparing the strains, researchers found a critical mutation that altered a key protein in the protective coating of newer Zika viruses. This single change greatly enhanced Zika's ability to infect, damage and destroy human precursor brain cells, they said.

An evolutionary analysis revealed that this change likely arose sometime in 2013, just a few months before an explosive outbreak of Zika in French Polynesia. That timing coincides with the first reports linking Zika to microcephaly and Guillain-Barre syndrome, a neural disorder that causes muscle weakness and paralysis in adults.

"They've concluded it looks like the contemporary virus is more virulent than its ancestors," said Dr. Richard Temes, director of the Center for Neurocritical Care at North Shore University Hospital in Manhasset, N.Y. "When patients are infected, it's more likely to lead to neurological disease than the former strains."

Although the analysis "is in many ways a very good explanation of what happened," it needs to be both confirmed and expanded upon, Osterholm said. Research on animals does not always produce the same results in humans.

McCormick agreed. For example, he said, the conclusions leave open the possibility that a genetic trait in some humans might leave them more vulnerable to the threat posed by this Zika mutation.

"Clearly a lot of people got infected with this, and a lot more pregnant women got infected than had microcephalic children," McCormick said. "Is there a human side of this that may make some people with the right genetic background more susceptible to this particular mutation?"

The findings were published Sept. 28 in the journal Science.

More information

For more on Zika, visit the U.S. Centers for Disease Control and Prevention.