611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

NurseWise 24-Hour Crisis Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

NurseWise 24-Hr Crisis Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Health Sciences
Resources
Basic InformationLatest News
Better Diet, Bigger Brain?Primary Care Providers Have Mixed Views on Genetic TestsFDA Targets Clinics Offering Unapproved Stem Cell TherapiesRestless Legs Linked to Brain ChangesContact Sports May Alter the Brain, Scans SuggestJust One Concussion Could Raise Parkinson's RiskLove Your Hair Color? You Have Over 100 Genes to Thank.Too Much Sitting Could Raise Brain RisksBusting Myths Surrounding Cancer and Genetic TestingTough Times Can Leave Their Mark on the Older BrainSugar-Craving Gene Helps Lower Body Fat, But Has DownsideMajor Project Completes Genetic 'Map' of 33 CancersOlder Brains Replenish Cells Just Like Young Brains: StudyScientists Say They Discovered a 'New Organ' in the BodyNew Technology Gives 'Feeling' to Prosthetic ArmsBlood Pressure Check? There May Soon Be an App for ThatHealth Tip: What You Can Learn From Genetic TestingAs Stroke 'Liquefies' Brain Tissue, Lasting Harm May SpreadClues to Parkinson's May Be Shed in TearsFDA Approves First Blood Test to Evaluate Potential ConcussionsLimited Evidence for Effect of Cranial Electrical StimulationAutism, Bipolar and Schizophrenia Share Genetic SimilaritiesDo Over-the-Counter Painkillers Alter Emotions, Reasoning?Specific White Matter Patterns Linked to Youth PsychopathologyA New Way to Thwart Disease-Spreading MosquitoesFirst Monkeys Cloned From Process That Created 'Dolly' the SheepNeil Diamond Reveals Parkinson's DiagnosisBrain Is Susceptible to Acute MI, Chronic Heart FailureBrain Zaps May Help Curb Tics of Tourette SyndromeScientists Turn Skin Cells Into Muscle Cells, a Potential Boon for ResearchRobot Training Improves Gait Stability in Parkinson'sCould an Electric Pulse to the Brain Recharge Your Memory?Genes Start Mutating Soon After Life Begins, Study FindsMore Men Than Women With Parkinson's Have Caregivers'Fountain of Youth' Gene Discovered in Secluded Amish CommunityLRRK2 Variants Linked to Lower Age at Onset of Parkinson'sKnowing Too Much About Your Genes Might Be RiskyOverlapping Surgery Appears Safe in Neurosurgical ProceduresDo I Know Ewe?Daytime Wounds May Heal Faster Than Nighttime OnesHuman vs. Animal Brainpower: More Alike Than You Might ThinkResilient Brain Connections May Help Against Alzheimer'sConcerns Surround Use of Direct-to-Consumer Genetic TestingWhen It Comes to Obesity, Genes Just Partly to BlameDoes Time of Neurosurgery Matter?Smoking Alters Genetic Relationship with Parkinson'sHealth Tip: Considering Genetic TestingDiabetes Ups Risk of MACE in Acute Coronary SyndromesScientists Spot Genes Behind Skin ColorScientists Support Genome Editing to Prevent Disease
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

Whole-Genome Sequencing of Uncertain Clinical Utility


HealthDay News
Updated: Jun 27th 2017

new article illustration

TUESDAY, June 27, 2017 (HealthDay News) -- Whole-genome sequencing of healthy people reveals that while some are at risk for rare genetic diseases, the implications remain unknown, according to a study published online June 26 in the Annals of Internal Medicine.

Researchers analyzed nearly 5,000 genes associated with rare genetic conditions in 50 healthy people. The investigators found that 11 of the people -- almost one-quarter -- had gene variants predicted to cause previously undiagnosed rare diseases.

Two of those 11 patients had signs or symptoms of the underlying conditions. One had variants linked to fundus albipunctatus. The second had a variant associated with variegate porphyria, which explained the patient's rashes and sun sensitivity. The other nine patients had no evidence of the diseases predicted by the genetic testing. For example, two patients had gene variants associated with heart rhythm abnormalities, but their hearts showed no signs of problems.

"In conclusion, we found that about one in five generally healthy patients receiving whole-genome sequencing results in a primary care setting had a new molecular diagnosis, and only one in 25 had a new clinical diagnosis," the authors write. "Although some primary care physicians may be able to manage the results appropriately, whole-genome sequencing may prompt additional clinical actions without evidence of short-term distress or clinical utility."

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)