611 W. Union Street
Benson, AZ 85602
(520) 586-0800

Health Choice Integrated Care crisis Line
1-877-756-4090

NurseWise 24-Hour Crisis Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530



SEABHS
611 W. Union Street
Benson, AZ 85602
(520) 586-0800

NurseWise 24-Hr Crisis Line
1-866-495-6735

NAZCARE Warm Line
1-888-404-5530


powered by centersite dot net

Getting Started
Here are some forms to get started. These can be printed and brought with you so that you can pre-fill out some known info ahead of time. More...


Health Sciences
Resources
Basic InformationLatest News
Why Your Nose May Be Key to Parkinson's RiskEvolution Not Over for HumansBrain Scans Offer Clues to Why Some Teens Pile on PoundsNew Clues to Why Yawns Are ContagiousNew Hope From Old Drugs in Fight Against Parkinson'sFirst Gene Therapy Approved in U.S.Awake for Aneurysm Brain Surgery, Better Results?Does Autism Risk Reside in Cells' Energy Engines?More Evidence Contact Sports Can Affect the BrainVirtual House Calls for Speedy, Effective Parkinson's CareSeven Imaging Biomarkers Tied to Cognition in Male FightersDiabetes Drug Shows Promise Against Parkinson'sCombined MRI Might Help Predict Brain Damage in BoxersMedical Reality Catches Up to Science FictionNoninvasive Brain Test May Pinpoint Type of DementiaIn Mice, Brain Cells Discovered That Might Control AgingScans May Show Consciousness in 'Comatose' PatientsBoxers, MMA Fighters May Face Long-Term Harm to Brain: StudyFDA Panel OKs What May Soon Be First Gene Therapy Approved in U.S.Early Parkinson's May Prompt Vision ProblemsWhole-Genome Sequencing of Uncertain Clinical UtilityCould Shift Work Damage Your DNA?Gene Sequencing May Reveal Risks for Rare DiseasesRogue Genes May Cause Some ALS CasesSticky Brain 'Plaques' Implicated in Alzheimer's AgainEven Your Bones Can Get Fat, Mouse Study SuggestsDoes a Low-Fat Dairy Habit Boost Parkinson's Risk?MicroRNA Biomarker Signature Identified for Allergic AsthmaHaywire Immune Cells May Help Cause BaldnessRegion in Brain Associated With Fear of Uncertain FutureBrain Scans Spot Where Fear and Anxiety LiveGene Therapy Might Someday Mend Badly Broken BonesLife Expectancy Slighter Shorter With Parkinson's, DementiaStudy Looks at Parkinson's Effect on Life SpanBody Cooling May Help Brain After Cardiac ArrestDo You Overeat? Your Brain Wiring May Be WhyGene Mutation May Speed Alzheimer's DeclineIs This Enzyme Making You Fat?Type 2 Diabetes May Be Bad for Brain Health'Brain Age' May Help Predict When You'll DieParkinson's Disease May Originate in Gut, Study SaysBlood-Based Genome Testing Feasible for Rapid Mutation AssayBlood Test May Gauge Death Risk After Surgery150-Year-Old Drug May Shorten 'Off' Time for Parkinson's PatientsBrain May Be Organized by Functions, Not Body PartsBody Temperature Might Give Clues to ComaCould Young Blood Boost the Aging Brain?A 'Brainwave' to Help Fight PTSDDizziness in Parkinson's May Be Due to Cerebral HypoperfusionMisunderstood Gene Tests May Lead to Unnecessary Mastectomies
Questions and AnswersLinksBook Reviews
Related Topics

Medical Disorders
Mental Disorders
Mental Health Professions

Respiratory Muscle Strength Can Predict Survival in ALS


HealthDay News
Updated: Jan 5th 2017

new article illustration

THURSDAY, Jan. 5, 2017 (HealthDay News) -- Respiratory muscle strength assessments can predict survival or ventilator-free survival in amyotrophic lateral sclerosis (ALS), according to research published online Dec. 30 in the American Journal of Respiratory and Critical Care Medicine.

Michael I. Polkey, Ph.D., from the Royal Brompton and Harefield National Health Service Foundation Trust and Imperial College London, and colleagues compared the predictive power of invasive and noninvasive respiratory muscle strength assessments for survival or ventilator-free survival using data from a previously published report with respiratory muscle strength measurements for 78 patients with ALS.

The researchers found that each respiratory muscle strength assessment achieved statistical significance individually for the prediction of survival or ventilator-free survival. Significant predictors of ventilator-free survival included sniff trans-diaphragmatic and esophageal pressure, twitch trans-diaphragmatic pressure (Tw Pdi), age, and maximal static expiratory mouth pressure, in multivariate analyses; for absolute survival, predictors included Tw Pdi and maximal static expiratory mouth pressure. Differing sensitivities were seen for measures, although they all had good specificity. For vital capacity, all cut-off points were greater than 80 percent of normal, except for prediction of three-month outcomes. There was a linear decline for direct measures of respiratory strength, while little to no decline was seen in vital capacity until 12 months before death/ventilation.

"The most powerful biomarker for mortality stratification was Tw Pdi, but the predictive power of sniff nasal inspiratory pressure was also excellent," the authors write.

Ismar Healthcare supported the editing of the manuscript, which was funded by BioMarin Pharmaceutical; two authors are employees of BioMarin.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)